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The study "Current trends and approaches to media literacy in Europe" has been carried out for the Commission by the Universidad Autonoma de Barcelona in the second half of 2007. The objective was to map current practices in implementing media literacy in Europe. The study covers the 27 Member States of the European Union and the EEA Member States.
You can download the study below. More information can be found on the EU Commission page . You can also find there country profiles from , , , , , , , , , and the .
Please also have a look into the attached papers from Nicolas Carbonell about the and Christos Christodoulou about the . Also the paper from Alexander Fedorov about the .
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The penis is the male sexual organ. It contains:
What is an undescended testicle?
Thinking that your partner is reacting negatively to you
Prognosis Many men will experience episodes of ED that improve without the need for treatment. Sometimes, persistent ED can be the result of a more serious underlying health condition, such as heart disease. In such cases, treatment will be needed to treat the underlying condition.
Mild occasional burning or discomfort (experienced by approximately one third of patients)
Erectile dysfunction (ED), also known as impotence, is the inability to achieve or sustain an erection for satisfactory sexual activity.
Sildenafil should initially be prescribed at 50 mg to be taken one hour before anticipated intercourse. The dose can be increased to 100 mg if needed. A 25-mg tablet is also available; this should be the starting dose for men older than 65 and in patients with hepatic or renal dysfunction. Sildenafil should not be used more than once a day and should not be used in combination with other drugs for erectil23e dysfunction. As of this writing, the drug cost to pharmacists is approximately $263 for 30 tablets of any size. This translates to an average wholesale price of $8.75 per tablet, which has prompted some insurers to limit the number of tablets they will pay for on a monthly basis.
"At the present time, there is no consensus or standard of care for optimal management of the cardiac complications of dystrophinopathies, and further research in this area is clearly needed," Cwik said.
Figure 3. Sildenafil improves the efficacy of ACT. BALB/c mice were challenged s.c. with either C26GM (A) or 4T1-HA (B) cells on day 0. Tumor-specific T cells were transferred on day 1. Sildenafil treatment was started on day 1. Tumors were surgically removed and weighed (right) either on day 10 (A) or 21 (B). *, PA < 0.00001 by using one-way ANOVA; +, PT < 0.001 by using a paired t test comparing sildenafil to sildenafil + ACT groups. Error bar values are shown.
Success rate of 70-80%
Sildenafil is a potent inhibitor of PDE-5, the enzyme that acts in the corpora to break down cGMP. This action is mediated by the secondary neurotransmitter NO, which is primarily responsible for smooth muscle relaxation within the corpora cavernosa. The inhibition of PDE-5 slows the degradation of NO, which enhances its effect. This permits the development of an improved and sustainable erection.
SOURCE: Sleep, January 2010.
Giovanni Corona & Mario Maggi
To exert a measurable antitumor effect, tumor-specific T cells must be present in sufficient numbers and capable of trafficking to their targets. A direct correlation exists between the number of tumor-infiltrating lymphocytes (TILs) and a favorable clinical outcome, as demonstrated in patients with metastatic ovarian cancer (20). Furthermore, the functional status of TILs has been correlated with a favorable prognosis in various human malignancies (20–24). Because PDE5 inhibition augments antitumor immunity, we asked whether sildenafil treatment altered both the number and activation state of TILs. Histological examination of CT26WT tumors revealed a greater intratumoral cellular infiltrate in the sildenafil-treated mice compared with the untreated controls (Fig. 4 A). To better evaluate these differences, C26GM-bearing mice received either tumor-primed or no T cells followed by sildenafil treatment or no additional therapy. The tumors were excised 9 d later, and single cell suspensions were obtained. The T cell infiltrate was analyzed by flow cytometry for CD4+ and CD8+ T cells. This approach enabled us to accurately examine the entire tumor mass and reliably quantify the infiltrating lymphocytic population. Although no increase in CD4+ T cells was observed with PDE5 inhibition (Fig. 4 B, inset), sildenafil treatment greatly increased CD8+ intratumoral infiltration with up-regulation of the activation markers CD69 and CD25 (Fig. 4 C). There were no differences in activation markers between the sildenafil-treated group and sildenafil + ACT, whereas a significant increase in intratumoral T cells were observed in the sildenafil + ACT–treated group compared with sildenafil alone (Fig. 4 B and Fig. S4, available at http://www.jem.org/cgi/content/full/jem.20061104/DC1).
Sharlip says he thinks it's dangerous to take your doctor out of the loop by buying Viagra on the Internet, for example. "Internet acquisition of these drugs is the same thing as over-the-counter," he says. "They say there's a physician that's overseeing it, but there's no physician overseeing it very carefully."
Still, the advance does mark one of the few breakthroughs against the disorder in years, Sharlip said. And he added that success in tissue engineering has implications "not only for the treatment of erectile dysfunction but in the world of medicine in general."
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