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High blood pressure What is premature ejaculation? Neurologic Conditions Premature Ejaculation Of 977 subjects who received double-blind medication, 774 (79.2%) completed the course of treatment. Several doses were used, but patients in all of the apomorphine dose groups reported erections firm enough for penetration more often than those taking placebo (P <.01). When separated according to dose, firm erections were reported by 45% versus 35% of the control group with the 2-mg dose. The 4-mg dose elicited positive responses in 55%, compared with 36% in the placebo group. With the 6-mg dose, 60% reported positive responses, compared with 32% in control subjects. Adverse events occurring in 10% or more of the patients in any group were nausea, sweating, dizziness, somnolence, vomiting, yawning, and asthenia. Most of these were considered mild to moderate in severity. Nausea was the most common adverse effect, which was found to be dose-related and reducible with repeated exposure to the drug. Prescribing and Price Bob Dole is hawking Viagra. The ad, sponsored by the drugs manufacturer, Pfizer, seems to be everywhere in the print and broadcast media. Words like "courage" and "worthwhile" leap from the ad, as the former senator urges men to speak to their doctors about erectile dysfunction, the new term for impotence. In keeping with the current trend in prescription drug advertising, Viagra isnt mentioned in the ad. Instead, Pfizer is selling the illness of erectile dysfunction, or E.D., as it is referred to throughout the ad. Overtraining Tests such as the bulbocavernosus reflex test are used to determine if there is sufficient nerve sensation in the penis. The physician squeezes the glans (head) of the penis, which immediately causes the anus to contract if nerve function is normal. A physician measures the latency between squeeze and contraction by observing the anal sphincter or by feeling it with a gloved finger inserted past the anus. Specific nerve tests are used in patients with suspected nerve damage as a result of diabetes or nerve disease. ERECTILE DYSFUNCTION buy canadian viagra DATA SOURCES: Primary research and review articles were identified through a search of ScienceDirect, PubMed/MEDLINE, and International Pharmaceutical Abstracts (1990ľAugust 2004). The following search terms were used in the Medicine Dentistry and Pharmacology, Toxicology, and Pharmaceutical Sciences subcategories: phosphodiesterase 5 inhibitor, PDE5 inhibitor, erectile dysfunction, sildenafil, vardenafil, tadalafil, prostatectomy, and diabetes. Web of Science (1990ľAugust 2004) was used to search for additional abstracts using the same search terms as above. The package inserts for sildenafil, vardenafil, and tadalafil were also consulted. Transurethral Alprostadil In addition to particular disorders, erectile dysfunction may also be a side effect of medications. Medications associated with erectile dysfunction include those used to treat: hMaxi-K Sildenafil is a potent inhibitor of PDE-5, the enzyme that acts in the corpora to break down cGMP. This action is mediated by the secondary neurotransmitter NO, which is primarily responsible for smooth muscle relaxation within the corpora cavernosa. The inhibition of PDE-5 slows the degradation of NO, which enhances its effect. This permits the development of an improved and sustainable erection. "The results of our meta-analysis are not surprising, but give strength to the general notion that this class of drugs is efficient and safe for this specific wide population," review lead author Dr. Moshe Vardi, of the internal medicine division at Lady Davis Carmel Medical Center in Israel, said in a prepared statement. The researchers found that men who said they had sexual intercourse less than once a week had twice the risk of developing erectile dysfunction, compared with men reporting having sexual intercourse once a week.